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Selected research publications

Innate immunity acts directly on viral translation

Damian Kim, Frank McCarthy, Kathy Li, Robert J. Chalkley, John Pak, Joshua E. Elias, Aviner R. ADAR1 Restricts Poliovirus Infection through dual disruption of translation initiation and protein coding. biorXiv 2025

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Ribosome dysfunction drives proteotoxicity in Huntington's disease

Aviner R, Lee, TT, Li K, Masto VB, Gestaut D, Andino R, Frydman J. Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease. Nature Cell Biology 2024

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SARS-CoV-2 rewires access to the translation machinery

Aviner R, Lidsky PV, Xiao Y, Tassetto M, Kim D, Zhang L, McAlpine PL, Elias J, Frydman J, Andino R. SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA. PLoS Pathogens, 2024. 

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Engineered viral genomes produce immunity without disease

Xiao Y, Lidsky P, Shirogane Y, Aviner R, Li W, Catching BA, Talbot D, Doitsh G, Su W, Gekko CE, Zheng W, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, Jackson PK, Frydman J, Andino R. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. Cell 2021

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Cotranslational protein biogenesis creates a druggable viral dependency

Aviner R, Li K, Frydman J, Andino R. Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis. Nature 2021

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Mapping the molecular environment of translating ribosomes during mitosis

Aviner R, Hoffman S, Elman T, Shenoy A, Geiger T, Elkon R, Ehrlich M, Elroy-Stein O. Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis. Nucleic Acids Research 2017

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Multi-omic data integration for gene expression analysis

Aviner R, Shenoy A, Geiger T, Elroy-Stein O. Uncovering hidden layers of cell cycle regulation through integrative multi-‘omic’ analysis. PLoS Genetics 2015

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Measuring protein synthesis directly by mass spectrometry

Aviner R, Geiger T, Elroy-Stein O. Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P). Nature Protocols 2014

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Discovering translational regulation at proteome scale

Aviner R, Geiger T, Elroy-Stein O. Novel proteomic approach reveals cell cycle specific fluctuations in mRNA translation. Genes & Development 2013

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Selected Reviews

Review: the use of puromycin and its derivatives for translation studies

Aviner R. The science of puromycin: from studies of ribosome function to applications in biotechnology. Computational and Structural Biotechnology Journal 2020

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Review: how viruses depend on host chaperones for productive infection

Aviner R, Frydman J. Proteostasis in viral infection: unfolding the complex virus–chaperone interplay. Cold Spring Harb Perspect Biol. 2020

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