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    • Home
    • Research
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  • Home
  • Research
  • Publications
  • About
  • Values
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Selected publications

Collided ribosomes cause cell death in Huntington's Disease

Aviner R, Lee, TT, Li K, Masto VB, Gestaut D, Andino R, Frydman J. Ribotoxic collisions on CAG expansions disrupt proteostasis and stress responses in Huntington’s Disease. BiorXiv 2022

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Engineered virus induces protective immunity without disease

Xiao Y, Lidsky P, Shirogane Y, Aviner R, Li W, Catching BA, Talbot D, Doitsh G, Su W, Gekko CE, Zheng W, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, Jackson PK, Frydman J, Andino R. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. Cell 2021

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Drugs targeting ribosome interactors reduce viral infection

Aviner R, Li K, Frydman J, Andino R. Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis. Nature 2021

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Review: puromycin in biotechnology

Aviner R. The science of puromycin: from studies of ribosome function to applications in biotechnology. Computational and Structural Biotechnology Journal 2020

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Review: viruses and protein folding

Aviner R, Frydman J. Proteostasis in viral infection: unfolding the complex virus–chaperone interplay. Cold Spring Harb Perspect Biol. 2020

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Splicing factors regulate translation during cell division

Aviner R, Hoffman S, Elman T, Shenoy A, Geiger T, Elkon R, Ehrlich M, Elroy-Stein O. Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis. Nucleic Acids Research 2017

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Multi-omic analysis informs cell cycle regulation

Aviner R, Shenoy A, Geiger T, Elroy-Stein O. Uncovering hidden layers of cell cycle regulation through integrative multi-‘omic’ analysis. PLoS Genetics 2015

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PUNCH-P for high-resolution analysis of protein synthesis

Aviner R, Geiger T, Elroy-Stein O. Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P). Nature Protocols 2014

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Proteomic analysis of nascent chain dynamics in cell division

Aviner R, Geiger T, Elroy-Stein O. Novel proteomic approach reveals cell cycle specific fluctuations in mRNA translation. Genes & Development 2013

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